Status:
TERMINATED
Endothelial Damage and Atherosclerosis in Obstructive Sleep Apnea
Lead Sponsor:
The University of Hong Kong
Conditions:
Obstructive Sleep Apnea
Insulin Resistance
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The investigators hypothesize that obstructive sleep apnea (OSA) may lead to increased formation/accumulation of advanced glycation ends (AGEs), and that the increase in AGEs is contributed in part by...
Detailed Description
There is growing evidence to suggest that pathophysiology of OSA may lead to atherosclerosis, independent of confounding variables which are often present in these subjects with OSA. Many mechanisms h...
Eligibility Criteria
Inclusion
- age 18-65 years old
- AHI \>= 15
- BMI \< 35
Exclusion
- Known cardiovascular disease, including hypertension
- Diabetes
- Acute or unstable chronic disease
- Renal failure
- Major organ system failure, including liver, renal, cardiac and respiratory failure
- Taking long-term medications
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00942643
Start Date
May 1 2008
End Date
March 1 2010
Last Update
July 4 2012
Active Locations (1)
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1
Queen Mary Hospital
Pokfulam, Pokfulam, Hong Kong