Status:
COMPLETED
Restrictive and Liberal Transfusion Strategies in Intensive Care
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
NHS Lothian
Chief Scientist Office of the Scottish Government
Conditions:
Intensive Care
Blood Transfusion
Eligibility:
All Genders
55+ years
Phase:
NA
Brief Summary
The most effective transfusion practice in critically ill ICU patients is unknown. Currently the data is unclear as to whether a liberal or restrictive transfusion policy is of most benefit to patient...
Detailed Description
Anaemia is a common complication of critical illness and 40-50% of all patients in intensive care units (ICUs) receive blood transfusions. However, despite the perceived benefits of correcting anaemia...
Eligibility Criteria
Inclusion
- The patient remains in the ICU after 96 hours (4 days) or more following ICU admission
- The patient has required mechanical ventilation via an endotracheal tube or tracheostomy tube for 96 hours or more
- The patient is expected to require ≥24 hours of further mechanical ventilation at the time of assessment
- The patient is aged ≥55 years of age
- The patient has a Hb value of 90g/L or less at the time of assessment
Exclusion
- Patient with active bleeding at the time of screening
- Patient with traumatic brain injury as presenting diagnosis
- Patient with intracranial haemorrhage as presenting diagnosis
- Patient not expected to survive the next 48 hours at the time of assessment.
- Patient objects to RBC transfusion
- Patient receiving concurrent treatment with erythropoietin or similar erythropoietic agent
- Follow up is not feasible
- Already enrolled in another RCT with similar clinical endpoints
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00944112
Start Date
August 1 2009
End Date
November 1 2010
Last Update
March 8 2011
Active Locations (6)
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1
Ninewells Hospital & Medical School
Dundee, United Kingdom, DD1 9SY
2
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom, EH16 2SA
3
Western General Hospital
Edinburgh, United Kingdom, EH4 2XU
4
The Royal London Hospital
London, United Kingdom, E1 1BB