Status:
COMPLETED
Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease
Lead Sponsor:
Stanford University
Collaborating Sponsors:
Palo Alto Veterans Institute for Research
Conditions:
Sleep Initiation and Maintenance Disorders
Eligibility:
All Genders
55-100 years
Phase:
NA
Brief Summary
The aim of this study is to demonstrate the efficacy of timed exposure to bright light for the treatment of disturbed nighttime sleep and daytime wake in community-dwelling dementia patients and their...
Detailed Description
1. Efficacy: Up to 4 weeks of morning bright light exposure will be more efficacious than morning dim light in consolidating nighttime sleep as assessed by actigraphy. 2. Predictors of response: We ex...
Eligibility Criteria
Inclusion
- Alzheimer's Disease Patients:
- Stanford Alzheimer's Disease Core Center member or potential member, with diagnostic criteria met for probable AD, living with caregiver willing to participate in the protocol
- Non-institutionalized
- Caregivers:
- Living in home of AD patient and willing to participate in protocol
Exclusion
- Alzheimer's Disease Patients:
- History of manic or bipolar disorder
- Prior bright light treatment
- Irregular or non-24 hour sleep/wake cycle
- Positive result on multi-staged RLS/PLMD
- Medical/Ophthalmologic Exclusions
- RDI \>20 on overnight EdenTrace® recording
- Caregivers:
- History of manic or bipolar disorder
- Medical/Ophthalmologic Exclusions
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
118 Patients enrolled
Trial Details
Trial ID
NCT00946530
Start Date
September 1 2004
End Date
December 1 2010
Last Update
October 3 2018
Active Locations (1)
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1
VA Palo Alto Health Care System
Palo Alto, California, United States, 94304