Status:
TERMINATED
Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity
Lead Sponsor:
University of California, San Francisco
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
In previous clinical studies of post-surgical pain the investigators found that nalbuphine (Nubain), a narcotic pain killer, relieves pain more effectively when combined with low-dose naloxone (Narcan...
Eligibility Criteria
Inclusion
- Age 18 - 40
- In stable health
- Speak, read, understand English language
- If female, must be non-lactating and not pregnant
Exclusion
- Heat pain detection thresholds above 47 ºC/116.6 ºF
- Inability to develop secondary hyperalgesia from the heat and capsaicin stimulation performed at the screening visit
- Serious psychiatric psychopathology (psychotic disorder, substance abuse)
- Tattoos in the area of measurements
- Allergy to study drugs (nalbuphine, naloxone, or capsaicin)
- Current or recent use opioids
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00947284
Start Date
January 1 2010
End Date
June 1 2012
Last Update
May 20 2016
Active Locations (1)
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1
University of California
San Francisco, California, United States, 94143