Status:
UNKNOWN
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Lead Sponsor:
Medical University of Lodz
Conditions:
Obstructive Sleep Apnea
Acute Kidney Failure
Eligibility:
MALE
18-70 years
Phase:
NA
Brief Summary
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide. OSA is a well estab...
Detailed Description
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide. Its prevalence may ...
Eligibility Criteria
Inclusion
- Males with high risk of obstructive sleep apnea syndrome as clinically assessed by coincidence of typical symptoms (e.g. daily somnolence, witnessed apnea, non-refreshing sleep), obesity and high score on Epworth sleepiness scale (ESS) with age range from 18 to 70 years
- Glomerular filtration rate (MDRD formula-based) \> 60 ml/min
- Arterial hypertension diagnosed according to the European Society of Hypertension 2007 Guidelines.
Exclusion
- Mental illness
- Proteinuria \>2 g/24h
- Acute and chronic inflammation
- Heart failure III or IV grade
- Uncontrolled diabetes mellitus
- Severe lipid disturbances (triglyceride and/or total cholesterol concentration \> 300 mg/dl)
- Chronic administration of drugs with confirmed nephrotoxicity and/or sympathicomimetics
- Obstructive and restrictive pulmonary diseases which may deteriorate the function of the respiratory system
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2011
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00947479
Start Date
February 1 2009
End Date
July 1 2011
Last Update
July 28 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical University
Lodz, Łódź Voivodeship, Poland, 90-153