Status:
COMPLETED
Improving Latent Tuberculosis (TB) Diagnosis in Thai Children
Lead Sponsor:
SEARCH Research Foundation
Collaborating Sponsors:
Columbia University
New York Blood Center
Conditions:
Latent Tuberculosis
HIV Infections
Eligibility:
All Genders
2-16 years
Brief Summary
The study is a prospective study to improve the diagnosis and management of latent TB in HIV-infected and HIV uninfected children in Thailand. The objectives are to assess the sensitivity and specific...
Detailed Description
Study Objectives * To compare the utility of IGRAs, T-Spot®.TB and QuantiFERON®-TB Gold In-Tube, and TST for screening of latent TB in HIV-infected children * To compare these different screening mod...
Eligibility Criteria
Inclusion
- Have close contact with a person \> 15 years of age who had active pulmonary (± extrapulmonary), sputum AFB positive TB (household member or non-household member with contact \> 120 hours/month) during the past year
- Are between the ages of 2 months and 16 years
- Parents or caregivers provide informed consent to participate
- Provide child assent for children aged ≥ 7 years
Exclusion
- Child and/or parent/caregiver who refuse study participation
- Are currently receiving antituberculosis medications for TB disease
- Have recently been diagnosed with active TB within past 6 months
Key Trial Info
Start Date :
August 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
158 Patients enrolled
Trial Details
Trial ID
NCT00947609
Start Date
August 1 2009
End Date
December 1 2011
Last Update
June 6 2012
Active Locations (2)
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1
HIV Netherlands Australia Thailand (HIV-NAT) Research Organization
Bangkok, Thailand
2
Queen Sirikit National Institute of Child Health
Bangkok, Thailand