Status:
COMPLETED
Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome
Lead Sponsor:
Royan Institute
Conditions:
Endocrine System Diseases
Gonadal Disorders
Eligibility:
FEMALE
18-30 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to compare the effectiveness of low dose human chorionic gonadotropin (HCG) in combination with clomiphen citrate to induce ovulation and its endocrine response in patient...
Detailed Description
Infertile women with PCOS, who have showed resistance to Clomiphen Citrate (150 mg- 5 days) in a previous IUI treatment cycle at Royan Institute (Infertility and Reproductive Medicine Research Centre)...
Eligibility Criteria
Inclusion
- Women with PCOS diagnosed by the Rotterdam criteria
- Previously documented dominant follicle or follicles (R12 mm mean diameter) on transvaginal Ultrasound follicular monitoring while receiving CC at the 150-mg dose in our clinic but have failed to ovulate;
- Primary infertility
- Documented normal uterine cavity and patent tubes by either hysterosalpingogram or laparoscopy and hysteroscopy;
- Male partner had to have a normal semen analysis by World Health Organization criteria.
Exclusion
- previous history of IVF or ICSI treatments.
- History of hormonal treatment within recent three month (Except OCP, progesterone).
- History of ovarian cutter or Ovarian drilling.
- BMI higher than 30.
- The presence of ovarian cyst (more than 30 mm) during third cycle ultrasound.
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00947713
Start Date
August 1 2009
End Date
December 1 2010
Last Update
July 15 2011
Active Locations (1)
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1
Royan institute, Reproductive Medicine Research Centre, ACECR
Tehran, Tehran Province, Iran