Status:
COMPLETED
Research Study on the Effects of Smoking on Arteries
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Smoking
Eligibility:
All Genders
18+ years
Brief Summary
The current proposal, will elucidate the role of oxidant stress (OS) on arterial function as measured by flow mediated vasodilation. In addition, the investigators will address the hypothesis, that a ...
Eligibility Criteria
Inclusion
- Chronic smokers (of between 4 and 20 years duration) and non-smokers will be recruited to the GCRC. Smokers will be allocated to a "light" group, smoking 4-10 cigarettes per day and a "heavy" smoking group who smoke 11-20 cigarettes per day.
- Non-smokers will be defined as those with a life time consumption of no more than 20 cigarettes, do not live or work in a smoky atmosphere.
- All individuals will have a normal history and clinical examination, including a normal EKG, urinalysis and serum chemistry, haemogram and negative urinary pregnancy test.
Exclusion
- previously suffered an acute major cardiovascular event
- those with a chronic disease
- those taking chronic medication
- those with a history of alcoholism or substance abuse
- Ex-smokers
- Subjects, who have less than or equal to 60% platelet aggregation in response to arachidonic acid
Key Trial Info
Start Date :
January 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2006
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT00948454
Start Date
January 1 2003
End Date
June 1 2006
Last Update
October 27 2009
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104