Status:
COMPLETED
Study of the Effects of Iron Levels on the Lungs at High Altitude
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
Universidad Peruana Cayetano Heredia
Conditions:
Pulmonary Hypertension
Mountain Sickness
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
The study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels. The purpose of this study is to determine w...
Detailed Description
Pulmonary hypertensive disorders frequently complicate hypoxic lung disease and worsen patient survival. Hypoxia-induced pulmonary hypertension is also a major cause of morbidity at high altitude. Hyp...
Eligibility Criteria
Inclusion
- SLR ARM
- sea level natives of lowland ancestry
- generally in good health
- detectable tricuspid regurgitation on echocardiography
Exclusion
- any significant medical problem
- known susceptibility to high altitude pulmonary or cerebral oedema
- taking medications or iron supplements
- CMS ARM
- Inclusion Criteria:
- diagnosis of chronic mountain sickness
- no recent venesection therapy (within 1 year)
- detectable tricuspid regurgitation on echocardiography
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT00952302
Start Date
October 1 2008
End Date
November 1 2008
Last Update
August 6 2009
Active Locations (1)
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1
Universidad Peruana Cayetano Heredia
Lima, Peru, 31