Status:
COMPLETED
Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Conditions:
Diabetes Complications
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of the study is to determine if pyridostigmine bromide improves heart rate variability of type 2 diabetes mellitus subjects with cardiovascular autonomic neuropathy.
Detailed Description
The reduced heart rate variability is associated with increased risk of death in patients with diabetes mellitus. Cholinesterase inhibition with pyridostigmine bromide increases heart rate variability...
Eligibility Criteria
Inclusion
- diabetes mellitus
Exclusion
- myocardial infarction
- acute ischemic syndromes
- second or third degree atrioventricular block
- active alcoholism
- thyroid dysfunction
- chronic obstructive pulmonary disease
- history of intolerance to pyridostigmine.
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00953914
Start Date
March 1 2005
End Date
May 1 2010
Last Update
July 7 2011
Active Locations (1)
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1
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil