Status:
COMPLETED
Observational Study of Iron Overload in Stem Cell Transplantation
Lead Sponsor:
Dana-Farber Cancer Institute
Conditions:
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
18-65 years
Brief Summary
Recent retrospective studies have suggested that iron overload is a clinically important problem in patients undergoing ablative stem cell transplantation. However, these studies relied on serum ferri...
Detailed Description
As above.
Eligibility Criteria
Inclusion
- Age ≥ 18 years.
- Histologically confirmed acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS)
- Planned allogeneic stem cell transplantation with myeloablative conditioning regimen (regardless of stem cell source or donor HLA match)
- Patients will be eligible even if they have had prior stem cell transplantation (autologous or allogeneic)
Exclusion
- Contraindication to magnetic resonance imaging (MRI):
- Patients with cardiac pacemakers, implanted cardiac defibrillator (ICD), cardiac electrodes, pacing wires, internal electrodes, cochlear, otologic or other ear implants, metallic fragments or foreign body, metallic prosthesis. Patients with surgical staples should not be imaged until 7 days post-op unless approved by a radiologist;
- Severe claustrophobia
- Note: a history of allergic reaction to gadolinium is not a contraindication to enrollment, as contrast will not be used.
- Inability to provide informed consent
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00954720
Start Date
March 1 2008
End Date
May 1 2011
Last Update
February 28 2013
Active Locations (1)
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1
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02115