Status:
UNKNOWN
Topiramate Treatment for Patients With Epilepsy and Learning Disability : A Prospective Observational Study
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Epilepsy
Eligibility:
All Genders
18+ years
Brief Summary
It has been estimated that 22 - 32% of people with mental retardation or learning disability have co-existing epilepsy. Despite such high prevalence and although there may be particular concerns over ...
Eligibility Criteria
Inclusion
- Patients aged 18 years or above
- Patients mental retardation and with newly diagnosed epilepsy requiring treatment, or with chronic epilepsy that is unsatisfactorily controlled (defined as at least 2 seizures during an 8-week retrospective baseline).
Exclusion
- History of nephrolithiasis or renal impairment
- Patients with absence seizures only
- History of status epilepticus in the previous 3 months while receiving appropriate antiepileptic drug therapy
- History of suicidal attempts or psychotic illness, psychiatric or mood disorders in the previous 6 months that required hospitalisation
- History of alcohol or drug abuse in the previous year
- Patients with progressive neurological conditions or terminal medical conditions.
- Patients whose seizures are thought to be of alcoholic, metabolic, neoplastic, infectious, or non-epileptic in origin (including psychogenic seizures).
- Chronic use of antacids, calcium supplements or high dose vitamin C.
- Women who are pregnant, lactating or without adequate contraception if they have child bearing potential.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2013
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00956696
Start Date
May 1 2009
End Date
June 1 2013
Last Update
August 11 2009
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, Hong Kong