Status:
COMPLETED
Study of the Protective Effect of Mechanism of Pentoxyfilline After Major Liver Resection Under Inflow Occlusion (Pringle Manoeuvre)
Lead Sponsor:
University of Zurich
Conditions:
Liver Regeneration
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
The investigators hypothecate that pentoxyfilline increase significantly the liver regeneration and reduces significantly ischemia and reperfusion (I/R) injury in major liver using aspartate aminotran...
Detailed Description
Liver resection is for many patients with primary or secondary hepatic malignancies the only curative treatment option. Often, the complete clearance of the hepatic tumor disease can be only achieved ...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Major liver resection (hemihepatectomies and extended hemihepatectomies) for benign and malignant lesions
- Macroscopic and microscopic normal liver parenchyma
- No underlying liver disease
- Normal preoperative liver tests (quick, bilirubin, AST, ALT)
- Signed informed consent
Exclusion
- Age \< 18 years
- Minor liver resections (less than hemihepatectomies) or wedge resections
- Macroscopic and microscopic appearance of liver fibrosis or cirrhosis
- Underlying liver disease such as viral hepatitis, cirrhosis, etc.
- Pathological preoperative liver tests (quick, bilirubin, AST, ALT)
- Intolerance to xanthine derivatives
- History of myocardial or cerebrovascular insult
- Total vascular exclusion during liver resection
- Intra-operative detection of unresectable tumor disease
- No signed informed consent
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00957619
Start Date
March 1 2006
End Date
January 1 2010
Last Update
February 10 2015
Active Locations (1)
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1
University Hospital Zurich, Department of Visceral and Transplantation Surgery
Zurich, Canton of Zurich, Switzerland, 8091