Status:
TERMINATED
Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant
Lead Sponsor:
Vanderbilt-Ingram Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Cancer
Eligibility:
All Genders
Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to chronic graft-versus-ho...
Detailed Description
OBJECTIVES: * To determine and define the biological basis of different subtypes of chronic graft-vs-host disease using a targeted single nucleotide polymorphisms approach in patients who have underg...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Underwent prior matched related or unrelated allogeneic stem cell transplantation (SCT)
- Presence OR absence of chronic graft-vs-host disease after day 100 and alive after day 180 post-transplantation
- No T-cell depleted SCT, cord blood transplantation, mismatched allogeneic transplantation, or autologous transplantation
- Available recipient and donor DNA (samples collected from the Vanderbilt University or the Fred Hutchinson Cancer Center tissue bank)
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
November 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT00957736
Start Date
November 1 2008
End Date
December 1 2008
Last Update
May 14 2013
Active Locations (3)
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1
Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville, Tennessee, United States, 37064
2
Vanderbilt-Ingram Cancer Center at Franklin
Nashville, Tennessee, United States, 37064
3
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States, 37232-6838