Status:
COMPLETED
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model
Lead Sponsor:
Danish Headache Center
Conditions:
Headache, Migraine
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.
Eligibility Criteria
Inclusion
- Healthy volunteers
Exclusion
- Tension headache
- All other primary forms of headache
- Cardiovascular, Central Nervous system (CNS) and autoimmune diseases
- Gastrointestinal disease
- Previous or clinical signs of mental illness or substance abuse.
- Participation in a clinical study of a medicinal product without regulatory approval or marketing authorisation within 1 month prior to this trial
- Pregnancy/nursing
- Daily intake of medication (except oral contraceptives)
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00957983
Start Date
August 1 2009
End Date
February 1 2010
Last Update
January 11 2011
Active Locations (1)
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1
Danish Headache Center
Glostrup Municipality, Denmark, 2600