Status:
COMPLETED
Effects of Nocturnal Non-invasive Ventilation in Patients With Amyotrophic Lateral Sclerosis
Lead Sponsor:
National Taiwan University Hospital
Collaborating Sponsors:
Taipei Veterans General Hospital, Taiwan
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Specific aims: Aim 1. To determine the incidence of hypoventilation in Amyotrophic Lateral Sclerosis (ALS) patients. Aim 2. To identify the clinical characteristics and risk factors associated . Ai...
Detailed Description
Objectives: Amyotrophic lateral sclerosis is the commonest motor neuron disease with incidence of 0.8 person-years in Chinese. Respiratory muscle function has been proposed to be a strong predictor of...
Eligibility Criteria
Inclusion
- ALS patients who:
- had FVC 40%-80% of predict
- Pimax \< 60 mmHg
- daytime PaCO2 \< 50 mmHg
Exclusion
- Refuse to participate
- Require mechanical ventilation
- Active neurologic event other than ALS
- Obstructive pulmonary disease
- Active infection
- Need sedatives or narcotics within 3 days of sleep study
- Participating in other study at the same time
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00958048
Start Date
January 1 2009
End Date
April 1 2013
Last Update
August 16 2013
Active Locations (1)
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1
Peilin Lee
Taipei, Taiwan, 100