Status:
COMPLETED
Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Dartmouth-Hitchcock Medical Center
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
50-90 years
Phase:
NA
Brief Summary
Endorphins are released in response to breathing difficulty and can modify the perception of breathlessness. In this randomized placebo-controlled trial, resistive breathing loads are used to provoke ...
Detailed Description
Study Design: The study is a randomized, double-blind, placebo-controlled investigation comparing the intravenous administration of: * normal saline, considered a placebo, is expected to have no eff...
Eligibility Criteria
Inclusion
- Male or female patient 50 years of age or older;
- A diagnosis of COPD defined by American Thoracic Society-European Respiratory Society criteria
- Current or former smoker with a smoking history of greater than or equal to 10 pack-years;
- A post-bronchodilator forced expiratory volume in one second (FEV1) greater than or equal to 30% predicted and less than or equal to 80% predicted; AND
- A post-bronchodilator FEV1/forced vital capacity ratio less than 70%; and clinically stable COPD.
Exclusion
- Any patient who has a concomitant disease that might interfere with study procedures or evaluation;
- Inability to perform resistive breathing maneuvers; OR
- Any current use of a narcotic medication.
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00958919
Start Date
August 1 2009
End Date
October 1 2010
Last Update
April 11 2013
Active Locations (1)
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1
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756-0001