Status:
COMPLETED
Effect of Inhaled Steroids on Glucose Regulation in Asthma Patients
Lead Sponsor:
The University of Hong Kong
Conditions:
Asthma
Eligibility:
All Genders
35-74 years
Brief Summary
Inhaled steroid has been the cornerstone in the treatment of asthma, which carries a huge patient population worldwide including Hong Kong. In general, the safety of long-term use of inhaled steroid h...
Detailed Description
Inhaled corticosteroids (ICS) have been shown to have many side effects that are consistent with systemic corticosteroids, suggesting that its systemic absorption can lead to adverse effects in the lo...
Eligibility Criteria
Inclusion
- Asthma patients who have follow-up in our asthma clinics; OR Eligible subjects belonging to 1996 population cohort, which represents the general population ie. same base population as the asthma patients
- Current inhaled corticosteroid users
Exclusion
- On maintenance oral steroid
- Oral steroid use within 180 days prior to study
- IDDM
- Known secondary causes for diabetes including pregnancy, cushing's syndrome and acromegaly
- Inhaled corticosteroid use for \< 6 months
- Asthma exacerbation in recent 1 month, yet without need for systemic steroid use, as previous study has shown increased insulin resistance in subjects with unstable asthma, in relation to the acute stress during attack, which subsequently returned to normal after 1 month on disease stabilization
Key Trial Info
Start Date :
August 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
1394 Patients enrolled
Trial Details
Trial ID
NCT00959348
Start Date
August 1 2007
End Date
July 1 2009
Last Update
August 14 2009
Active Locations (4)
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1
Kowloon Hospital
Hong Kong, Hong Kong
2
Kwong Wah Hospital
Hong Kong, Hong Kong
3
Queen Elizabeth Hospital
Hong Kong, Hong Kong
4
Queen Mary Hospital
Hong Kong, Hong Kong