Status:
COMPLETED
Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection
Lead Sponsor:
University of Illinois at Chicago
Collaborating Sponsors:
Pennington Biomedical Research Center
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Coronary Heart Disease
Obesity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The proposed research will demonstrate that alternate day modified fasting (ADMF) is a suitable alternative to daily calorie restriction (CR) for weight loss, weight maintenance, and heart disease pre...
Detailed Description
Overweight and obese individuals are at increased risk for coronary heart disease (CHD). Losing weight by means of dietary restriction greatly reduces vascular disease risk. The majority of studies ex...
Eligibility Criteria
Inclusion
- Inclusion criteria. Adult subjects meeting the following criteria will be eligible to participate:
- Age between 18 to 65 years old
- BMI between 25.0 and 39.9 kg/m2
- Previously sedentary (\<60 minutes/week of light activity corresponding to 2.5 to 4.0 metabolic equivalents (METs) for the 3 months prior to the study)
- Exclusion criteria. Subjects excluded from participating in the study include those who:
- Have a history cardiovascular disease (prior angina, myocardial infarction or stroke)
- Are diabetic (fasting blood glucose \> 126 mg/dl)
- Have a history of psychiatric disorders and/or eating disorders
- Are taking anti-depressant or anti-anxiety medications
- Are taking drugs that affect study outcomes (weight loss, lipid-lowering, or blood pressure drugs)
- Are not weight stable for 3 months prior to the beginning of study (weight gain or loss \> 4 kg)
- Are not able to keep a food diary or activity log for 7 consecutive days during screening
- Are perimenopausal or have an irregular menstrual cycle (menses that does not appear every 27-32 days)
- Are claustrophobic or have implanted electrical devices (cardiac pacemaker or a neurostimulator)
- Are pregnant, or trying to become pregnant
- Are smokers
Exclusion
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00960505
Start Date
September 1 2010
End Date
January 1 2015
Last Update
July 21 2020
Active Locations (1)
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1
University of Illinois, Chicago
Chicago, Illinois, United States, 60622