Status:
COMPLETED
O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
Stage I Mycosis Fungoides and Sezary Syndrome AJCC v7
Eligibility:
All Genders
19+ years
Phase:
PHASE1
PHASE2
Brief Summary
This phase I/II trial studies the side effects and best dose of carmustine when given together with O6-benzylguanine and to see how well they work in treating patients with stage IA-IIA cutaneous T-ce...
Detailed Description
PRIMARY OBJECTIVES: I. To determine the cutaneous T-cell Lymphoma (CTCL) response rate and safety of O6BG (O6-benzylguanine) /BCNU (carmustine) when given biweekly as two consecutive daily doses. SE...
Eligibility Criteria
Inclusion
- Diagnosis of CTCL stages IA-IIA by histopathology and immunohistochemistry in screening biopsies confirmed at Case Western Reserve University within 6 months of enrollment; biopsies may be performed at the site of collaborating institutions and shipped to University Hospitals of Cleveland-Case Western Reserve University (UHC-CWRU)
- Performance status Eastern Cooperative Oncology Group (ECOG) grade 0, 1, or 2
- Patients must have recovered from toxicity of prior treatment and have received no CTCL therapy other than emollition for at least 4 weeks, with the exception of topical corticosteroids, which may be used up to 2 weeks before the trial start date
- Patients must have signed a consent form indicating the investigational nature of the treatment and its potential side effects
- White blood cell (WBC) at least 3.5 x10E9/L
- Absolute neutrophil count (ANC) at least 1.6 x10E9/L
- Platelets \> 100,000/ul
- Bilirubin \< 1.5 mg/dL
- Serum glutamic oxaloacetic transaminase (SGOT) within normal range
- Creatinine =\< 1.5 mg/dL
- Electrolytes normal
- Controlled (diet and insulin) diabetes is permitted
- Demonstration of clinically normal lung function based on history and physical examination; patients with clinical evidence of pulmonary disease as determined by the investigator should have baseline lung function tests performed with demonstration of diffusing capacity of the lung for carbon monoxide (DLCO) \>= 70%; a DLCO single breath, adjusted for hemoglobin, will be utilized; we will not use DLCO/alveolar volume (VA) for inclusion or exclusion in this study
- Patients must have cutaneous disease that is amenable to biopsy and must be willing to undergo several sequential biopsies
- Must have failed at least one conventional treatment for CTCL other than topical corticosteroids; this includes phototherapy, topical mechlorethamine, topical or oral bexarotene, radiation therapy, photopheresis, chemotherapy, and immunomodulatory agents such as interferon and other retinoids
Exclusion
- Patients who have received prior treatment with topical or systemic BCNU or other nitrosoureas
- Patients with known central nervous system involvement or primary central nervous system (CNS) malignancies
- Patients with performance status ECOG grade 3 or 4
- Pregnant women, women who are breast feeding infants, or women with reproductive potential not practicing adequate contraception
- Patients with an active infection which requires hospitalization, or which may affect the patient?s safety if the patient was enrolled
- Patients with pulmonary disease as determined by history, physical examination, chest X-ray, or pulse oximetry with \< 70% predicted DLCO
- CTCL patients with stage IIB-IVB disease
Key Trial Info
Start Date :
February 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 8 2014
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00961220
Start Date
February 1 2010
End Date
April 8 2014
Last Update
May 22 2018
Active Locations (4)
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1
Henry Ford Hospital
Detroit, Michigan, United States, 48202
2
Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106-5065
3
Case Western Reserve University
Cleveland, Ohio, United States, 44106
4
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210