Status:
UNKNOWN
Intensive Exercise to Improve Mitochondrial Dysfunction in Pediatric Obesity
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Pediatric Obesity
Insulin Resistance
Eligibility:
All Genders
10-18 years
Phase:
NA
Brief Summary
Obesity and type 2 diabetes are occurring at epidemic rates in the United States and worldwide. The global burden of diabetes is estimated to double over the next 25 years. Obese children are at risk ...
Eligibility Criteria
Inclusion
- Girls and boys ages 10 to 18 years old
- Body mass index more than 95th percentile for age and gender
- Insulin resistance based on:
- Fasting parameters: Fasting insulin level, HOMA IR
- Oral glucose tolerance testing
- Mitochondrial function \> 1 median for normal based on control cohort
Exclusion
- Underlying medical problem with potential to affect growth, pubertal development or glucose homeostasis
- Chronic medical therapy with glucocorticoids, growth hormone, estrogen, progesterone, testosterone, or other medications with the potential to alter growth, pubertal development or glucose homeostasis within the proceeding 6 months
- Personal history of DM
- Inability to have MRI scan performed due to metal prosthesis or implant
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00962806
Start Date
August 1 2009
End Date
December 1 2012
Last Update
April 27 2012
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114