Status:
COMPLETED
Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant
Lead Sponsor:
City of Hope Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Chronic Myeloproliferative Disorders
Leukemia
Eligibility:
All Genders
18-120 years
Brief Summary
RATIONALE: Studying immune response to flu vaccine in patients who have undergone a stem cell transplant may help doctors plan the best treatment. PURPOSE: This clinical trial is studying flu vaccine...
Detailed Description
OBJECTIVES: * Examine the humoral and cellular memory immune responses to influenza immunization in patients who have undergone autologous or allogeneic hematologic stem cell transplantation. * Exami...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria:
- Patient at the City of Hope or Kaiser hospital who underwent prior autologous or allogeneic matched-related hematologic stem cell transplantation (HSCT) or matched-unrelated HSCT for treatment of hematological malignancies, including aplastic anemia or myelodysplastic syndromes
- Eligible (in accordance with physician's recommendation) to receive the vaccine influenza A serotypes specific for the 2006-2007 or 2007-2008 influenza season
- Eligible (in accordance with physician's recommendation) to receive the vaccine influenza A or B serotypes specific for the 2009-2010 or 2010-2011 influenza season
- Patients who are not vaccinated are followed under the study protocol once they are matched to a vaccinated patient on the date of transplant and source of transplant
- All HLA serotypes allowed
- Employee volunteer from the City of Hope
- Meets the requirements for influenza vaccination
- Eligible to receive the CDC recommended vaccine for influenza A serotypes specific for the 2007-2008 flu season as part of occupational health's vaccination initiative
- All HLA serotypes allowed
- PATIENT CHARACTERISTICS:
- Life expectancy \> 9 months
- No HIV seropositivity
- No hepatitis B or C seropositivity
- Hepatitis B-positive serology by vaccination allowed
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior influenza vaccination after transplantation
Exclusion
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
459 Patients enrolled
Trial Details
Trial ID
NCT00964821
Start Date
January 1 2007
End Date
May 1 2013
Last Update
November 7 2017
Active Locations (2)
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1
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010-3000
2
City of Hope Medical Group
Pasadena, California, United States, 91105