Status:
UNKNOWN
EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment
Lead Sponsor:
Korea University
Conditions:
Cirrhosis
Variceal Bleeding
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
Detailed Description
Both propranolol and endoscopic band ligation (EBL) are effective for prevention of variceal rebleeding. Recently several studies compared the efficacy of EBL alone and with a combination of propranol...
Eligibility Criteria
Inclusion
- Liver cirrhosis
- Age between 18 and 70 years
- Successful control of esophageal variceal bleeding within 6 weeks before enrollment
Exclusion
- Gastric variceal bleeding
- Patients with systolic blood pressure \<100 mmHg or basal heart rate \<60/min
- Portal vein thrombosis
- Prominent hepatic encephalopathy
- Coexisting untreated malignancy
- Severe cerebrovascular or cardiovascular disease, renal failure
- No previous history of endoscopic, radiologic, or surgical treatment for varices or ascites
- Contraindication to beta-blocker
- Pregnancy
- Refusal to give consent to participate in the trial
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2021
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT00966082
Start Date
August 1 2008
End Date
July 1 2021
Last Update
August 22 2017
Active Locations (1)
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1
Korea University Anam Hospital
Seoul, South Korea, 136-705