Status:
COMPLETED
Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding
Lead Sponsor:
Korea University
Conditions:
Variceal Bleeding, Cirrhosis
Eligibility:
All Genders
16-75 years
Phase:
PHASE4
Brief Summary
This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic the...
Detailed Description
In patients who are suspected to have variceal bleedings, pharmacologic therapy with vasoactive drugs such as terlipressin, somatostatin, and octreotide is recommended as soon as possible, even before...
Eligibility Criteria
Inclusion
- liver cirrhosis
- age between 16 and 75 years
- Patients who have upper GI bleeding symptoms (hematemesis or melena) within 24 hours before enrollment
- Patients whose systolic blood pressure \<100 mmHg or pulse rate \>100/min at the enrollment
- Patients who were not performed endoscopic or pharmacologic therapy for varices
- Signed informed consent
Exclusion
- Pregnancy
- Positive anti-HIV Ab
- A history of severe side-effects or contraindications to study drugs
- Severe cardiovascular diseases: acute myocardial infarction, A-V block, congestive heart failure, ischemic heart disease, hypertension (systolic blood pressure \>170 mmHg or diastolic pressure \>100 mmHg)
- Chronic renal failure
- Hepatocellular carcinoma with protal vein thrombosis
- Coexisting malignancy except hepatocellular carcinoma
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
1034 Patients enrolled
Trial Details
Trial ID
NCT00966355
Start Date
September 1 2006
End Date
May 1 2010
Last Update
March 19 2018
Active Locations (1)
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1
Korea University Anam Hospital
Seoul, South Korea, 136-705