Status:
COMPLETED
Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Conditions:
Neuropathic Pain
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study is designed to assess: 1. The impact of taking perioperative pregabalin on the incidence of chronic neuropathic pain and postthoracotomy syndrome at 3 months in patients who have undergone...
Detailed Description
Postthoracotomy pain syndrome is a rather frequent phenomenon. Its incidence, as reported in the literature, varies but is around 52% at 1 to 2 years after surgery. This syndrome is defined as a persi...
Eligibility Criteria
Inclusion
- Patients aged 18 to 80 years.
- Patients who are to undergo an elective thoracotomy in the lateral decubitus position.
- Patients who are ASA I to III inclusive.
Exclusion
- A contraindication to pregabalin.
- A contraindication to the epidural technique.
- The current use of drugs belonging to the class of opioids, NMDA receptor blockers, membrane stabilizing agents (lidocaine mesylates, flecainide) or topical coanalgesics (capsaicin cream, lidocaine patch).
- Previous use of pregabalin or gabapentin.
- Preexisting pain at the site where the surgical incision will be made.
- Presence of a coexisting chronic pain syndrome.
- A creatinine clearance of less than 60 mL/min.
- A previous ipsilateral thoracotomy.
- A recent history of alcohol and/or drug abuse.
- A known allergy to local anesthetics or hydromorphone.
- The inability to understand a verbal numerical pain scale (VNPS) despite previous instruction.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT00967135
Start Date
June 1 2010
End Date
April 1 2012
Last Update
April 12 2012
Active Locations (1)
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1
Centre Hospitalier de l'Université de Montréal (Hôpital Notre-Dame)
Montreal, Quebec, Canada, H2L 4M1