Status:
COMPLETED
Statin Drugs to Prevent Complications During Surgery
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborating Sponsors:
Canadian Anesthesiologists' Society
Heart and Stroke Foundation of Ontario
Conditions:
Inflammation
Myocardial Infarction
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
Patients undergoing non-cardiac surgery frequently experience perioperative cardiac complications that may be due to excess inflammatory reactions. Lipid lowering drugs called HMG-CoA reductase inhibi...
Detailed Description
Despite modern improvements in operative care, non-cardiac surgery is still associated with significant and costly cardiac complications. The incidence of major perioperative cardiac events varies, ra...
Eligibility Criteria
Inclusion
- elective high-risk surgery defined by use of the POISE criteria
- over 45 years of age
Exclusion
- lack of informed consent
- contraindication to statin (i.e. liver insufficiency or cirrhosis, active muscular disorder or myopathy, or previous adverse reaction to statin)
- pregnant
- enrolled in another conflicting study
- previously enrolled in STAR VaS
- presently using a statin drug
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00967434
Start Date
December 1 2007
End Date
December 1 2010
Last Update
June 12 2018
Active Locations (1)
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1
The Ottawa Hospital
Ottawa, Ontario, Canada, K1Y4E9