Status:
COMPLETED
Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
Robert L. Bacon Medical Foundation
Research to Prevent Blindness
Conditions:
Glaucoma
Sedation
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to learn if breathing nitrous oxide (also known as "laughing gas") changes the pressure in a person's eyes. Some patients who need regular eye exams to measure their eye p...
Detailed Description
An initial pre-anesthetic evaluation and physical examination will be performed by an attending anesthesiologist, and an eye exam will be performed by an attending ophthalmologist to determine suitabi...
Eligibility Criteria
Inclusion
- Adults aged 18-40
- American Society of Anesthesiologists Physical Classification System (ASA) Status 1-2
- Nil per os (NPO) prior to study (2 hrs clear liquids, 4 hrs milk, 6 hrs light food, 8 hrs heavy/greasy food)
Exclusion
- Lack of volunteer consent
- Pregnancy
- History of features suggestive of a difficult airway on pre-anesthetic evaluation and physical examination
- Active gastroesophageal reflux disease
- Active obstructive sleep apnea
- History of recent trauma
- History of pneumothorax or lung cyst
- History of Vitamin B12 deficiency
- History of recent middle ear surgery (\<3months)
- Current or recent (\<3 weeks) respiratory tract infection
- Any acute illness or exacerbation of chronic illness such as asthma, chronic lung disease etc.
- Any history of cardiac ischemia (angina), myocardial infarction, or cardiac dysrhythmia.
- Myopia greater than -3 spherical equivalents or hyperopia greater than +3 spherical equivalents
- History of eye surgery of any sort, including refractive surgery, cataracts, and vitrectomy
- History of any ocular disease or infection
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00967694
Start Date
August 1 2009
End Date
October 1 2011
Last Update
September 23 2014
Active Locations (1)
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1
OHSU
Portland, Oregon, United States, 97239