Status:
COMPLETED
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Subarachnoid Hemorrhage
Vasospasm
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.
Detailed Description
Each year, approximately 30,000 people suffer aneurysmal subarachnoid hemorrhage (SAH) in the United States. The most common and potentially treatable cause of secondary neurological injury in this po...
Eligibility Criteria
Inclusion
- Aneurysmal SAH confirmed by angiography
- Hemoglobin \< 12.5 gm/dl
- One of the following:
- Considered at increased risk for vasospasm by care team
- Angiographic vasospasm
- Delayed ischemic deficit
- Able to be studied within 2 weeks after subarachnoid hemorrhage
Exclusion
- Active Coronary Artery Disease
- Severe congestive heart failure
- Jehovah's witness
- Unable to obtain appropriately matched blood
- Other contraindications for transfusion
- Pregnancy
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00968227
Start Date
November 1 2007
End Date
August 1 2015
Last Update
April 17 2017
Active Locations (1)
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1
Washington University Medical Center
St Louis, Missouri, United States, 63110