Status:
COMPLETED
Effects of Methylprednisolone After Total Knee Arthroplasty
Lead Sponsor:
Hvidovre University Hospital
Collaborating Sponsors:
Lundbeck Foundation
Conditions:
Postoperative Pain
Postoperative Nausea and Vomiting
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty. The hypothesis is that pre-operative...
Detailed Description
In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total knee arthroplasty is still associated with postoperative pain and delayed ...
Eligibility Criteria
Inclusion
- Elective total knee arthroplasty
- Able to speak and understand danish
- Able to give informed consent
Exclusion
- Alcohol or medical abuse
- Allergies to local anesthetics or methylprednisolone
- Age \< 18 years
- Daily use of opioids or glucocorticoids
- Pregnancy or breastfeeding (fertile women)
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00968578
Start Date
August 1 2009
End Date
December 1 2009
Last Update
September 26 2012
Active Locations (1)
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1
Hvidovre University Hospital
Copenhagen, Hvidovre, Denmark, 2650