Status:
UNKNOWN
Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR)
Lead Sponsor:
Ankara University
Collaborating Sponsors:
The Scientific and Technological Research Council of Turkey
Conditions:
Mitral Regurgitation
Atrial Fibrillation
Eligibility:
All Genders
18-85 years
Brief Summary
The aim of this project is to determine the morphological criteria of apoptosis in atrial tissues of patients with AF versus SR at transcriptome and genomic size.
Detailed Description
Mitral valve regurgitation (MR) is the second most common valvular heart disease encountered in adults. Furthermore, atrial fibrillation (AF) is the most common cardiac arrhythmia seen in clinical pra...
Eligibility Criteria
Inclusion
- Patients with permanent atrial fibrillation or sinus rhythm and degenerative mitral valve regurgitation who require cardiac surgery
- Pulmonary hypertension (systolic PA \> 45 mmHg)
- Left ventricular ejection fraction \> 30%
Exclusion
- Paroxysmal AF or atrial flutter
- Second or third degree heart block
- Permanent pacemaker
- Wolff-Parkinson-White syndrome
- Brugada syndrome
- Ischemic or rheumatic mitral valve disease
- Dilated cardiomyopathy
- LVEF \< 30%
- Infective endocarditis, myocarditis
- Trauma
- Active HBV, HCV, HIV infection
- Chronic renal failure
- Autoimmune diseases
- Vasculitis
- Known genetic disorders
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00970034
Start Date
December 1 2008
End Date
December 1 2011
Last Update
September 3 2009
Active Locations (1)
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1
Ankara University Medical Faculty, Department of Cardiovascular Surgery,
Ankara, Turkey (Türkiye), 06340