Status:
COMPLETED
The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Analgesia
Eligibility:
MALE
20-35 years
Phase:
NA
Brief Summary
1. Introduction Paracetamol, an analgesic prescribed daily, has been in use for more than 50 years. Surprisingly, its mode of action is still unclear. One postulated mechanism is the reinforcement...
Eligibility Criteria
Inclusion
- Healthy male volunteers
- 20-35 years of age
- No known medical disorders
- BMI 18.5 - 39.9 (kg/m2)
Exclusion
- Known drug allergies (paracetamol, tropisetron)
- Excessive consumption of tobacco (more than 10 cigarettes a day)
- Excessive consumption of tea or coffee (more than 5 cups a day)
- Recreational drug addiction
- Consumption of any medication on the trial days
Key Trial Info
Start Date :
November 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00970450
Start Date
November 1 2009
End Date
April 1 2010
Last Update
January 29 2013
Active Locations (1)
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1
University Hospital of Basel
Basel, Basel, Switzerland, 4031