Status:
COMPLETED
Analgesic Effect of Peripheral Dexmedetomidine
Lead Sponsor:
The University of Hong Kong
Conditions:
Third Molar Extraction
Eligibility:
All Genders
18-50 years
Phase:
PHASE3
Brief Summary
Dexmedetomidine is an alpha 2-adrenoreceptor agonist, which provides sedation, analgesia and anxiolysis in clinical practice (Cortinez et al., 2004,Hall et al., 2000). Three types of alpha 2-adrenergi...
Detailed Description
The study protocol was approved by our local Institutional Review Board and written consent was obtained from all the participants. Eligibility for recruitment included American Society of Anesthesiol...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- American Society of Anesthesiologists (ASA) physical status I and II
- Age between 18 and 50 years of age with 4 bilateral impacted third molar teeth scheduled for extraction under general anaesthesia
- Exclusion criteria:
- Clinical history or electrocardiographic evidence of heart block
- Ischaemic heart disease
- Asthma
- Sleep apnoea syndrome
- Impaired liver or renal function
- Alcohol consumption in excess of 28 units per week
- Pregnancy
- Patient refusal
- Known psychiatric illness
- Chronic sedative or analgesic use, and regular use of or known allergy to dexmedetomidine, paracetamol or dextropropoxypheneopioids
- Patients with preoperative inflammation at the site of surgery were also excluded
Exclusion
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT00971178
Start Date
February 1 2006
End Date
March 1 2008
Last Update
December 11 2020
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