Status:
COMPLETED
Spinal Cord Compression Re-Treat Study
Lead Sponsor:
Cancer Trials Ireland
Conditions:
Pain
Radiation Toxicity
Eligibility:
All Genders
18-120 years
Phase:
PHASE2
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiat...
Detailed Description
OBJECTIVES: Primary * To determine the efficacy of a biologically effective dose-based re-irradiation strategy, in terms of the response rate (based on the mobility score using the Tomita scale wher...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- MRI-confirmed diagnosis of malignant spinal cord compression
- MRI of the entire spine performed
- Histologically proven malignancy
- No primary tumors of the spine or vertebral column
- Undergone previous radiotherapy to the involved area of the spinal cord (e.g., full segment and/or ≥ 2 cm in cranio-caudal of overlap between the 2 areas treated)
- Maximum biologically effective dose received from previous irradiation ≤ 90 Gy\_2
- Deemed not suitable for neurosurgical intervention at the time of initial assessment
- Patients deemed inoperable are eligible
- PATIENT CHARACTERISTICS:
- Karnofsky performance status 40-100%
- Short life expectancy
- No medical or psychiatric condition that, in the opinion of the investigator or research team, contraindicates participation in this study
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 27 2018
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00974168
Start Date
October 1 2007
End Date
September 27 2018
Last Update
July 29 2019
Active Locations (2)
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1
Saint Luke's Radiation Oncology Network
Dublin, Ireland, 6
2
Galway University Hospital
Galway, Ireland