Status:
COMPLETED
Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J)
Lead Sponsor:
Oxford University Hospitals NHS Trust
Conditions:
Bone Infection
Joint Infection
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The study will compare the outcomes of treating bone and joint infections with 6 weeks of intravenous antibiotics with 6 weeks of oral antibiotic treatment. The trial is of antibiotic "strategy" rathe...
Detailed Description
A long course of antibiotic therapy given by a "drip" (i.e. intravenous) is recommended treatment for many serious bacterial infections. It is costly and inconvenient for the patient to remain hospita...
Eligibility Criteria
Inclusion
- Is willing and able to give informed consent for participation in the study. Has a bone and joint infection one of the following categories;
- Native osteomyelitis.
- Native joint septic arthritis.
- Diabetic foot infection with osteomyelitis.
- Prosthetic joint associated infection.
- Discitis/ spinal osteomyelitis/ epidural abscess
- Has had at least 48 hours, but not more than 7 days, of IV antibiotic therapy already given after definitive surgical management.
- Has a clinical diagnosis of bacterial infection (caused by any organism excepting mycobacteria).
- Is clinically stable in the opinion of the study clinicians, has no further interventions to treat acute infection required or planned.
Exclusion
- Has Staph aureus bacteraemia.
- Has suspected bacterial endocarditis.
- Has suspected mediastinal infection.
- Has suspected central nervous system infection.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2017
Estimated Enrollment :
1054 Patients enrolled
Trial Details
Trial ID
NCT00974493
Start Date
June 1 2010
End Date
February 28 2017
Last Update
June 5 2020
Active Locations (2)
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1
Nuffield Orthopaedic Centre
Oxford, Oxfordshire, United Kingdom, OX3 7LD
2
Oxford Radcliffe Hospitals Trust
Oxford, Oxfordshire, United Kingdom, OX3 9DU