Status:
COMPLETED
Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy
Lead Sponsor:
Capital Medical University
Collaborating Sponsors:
State University of New York - Downstate Medical Center
Conditions:
Supratentorial Craniotomy Dysfunction
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to investigate the effect of lidocaine in antiarrhythmic dosage on postoperative cognitive dysfunction in supratentorial craniotomy.
Eligibility Criteria
Inclusion
- 18-60 years old, ASA physical status I or II, BMI\<30
- Scheduled for elective supratentorial craniotomy
- MMSE\<24 before operation
- Cooperative and given informed consent in person
Exclusion
- History of mental or psychiatric disorders
- Contraindicated to internal jugular venous catheterization
- Pregnant or lactating female
- History of systemic malignant tumor or diabetes
- Previously treated with this protocol or participated in another study within previous 30 days
- Suspected history of allergic reaction or intolerance to amides or other anesthetic agents in this study
- History of alcohol abuse and/or drug abuse within previous one year
- History or a family history of malignant hyperthermia
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00975910
Start Date
September 1 2009
End Date
December 1 2012
Last Update
May 22 2013
Active Locations (1)
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1
Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100050