Status:
COMPLETED
N-methylglycine (Sarcosine) Treatment for Depression
Lead Sponsor:
China Medical University Hospital
Collaborating Sponsors:
National Science and Technology Council, Taiwan
Conditions:
Major Depressive Disorder
Depression
Eligibility:
All Genders
18-55 years
Phase:
PHASE2
Brief Summary
Major depressive disorder is a complex disease and most currently available antidepressants aiming at monoamine neurotransmission exhibit limited efficacy and cognitive effects. N-methyl-D-aspartate (...
Detailed Description
Major depressive disorder is a complex disease and most currently available antidepressants aiming at monoamine neurotransmission exhibit limited efficacy and cognitive effects. Novel therapies via ma...
Eligibility Criteria
Inclusion
- Aged 18-55 years
- Fulfilled the DSM-IV criteria of major depressive disorder
- Had a 17-item Hamilton Rating Scale for Depression (HAMD-17)\>or= 18
- No DSM-IV diagnosis of substance abuse or dependence (including alcohol) within the past 6 months
- Had been drug free for \> 3 months
- Physically healthy and had all laboratory parameters within normal limits.
- Agree to participate in the study and provide informed consent
Exclusion
- Had history of epilepsy, head trauma or other major neurological or medical diseases
- Had psychotic depression, bipolar I/II disorder, schizophrenia or any other psychotic disorder
- Moderate-severe suicidal risks
- Severe cognitive impairment
- Female subjects who were pregnant, or at risk of pregnancy or lactation
- Initiating or stopping formal psychotherapy within six weeks prior to enrollment
- Had a history of poor response to SSRIs or previously received electroconvulsive therapy
- Had a history of severe adverse reaction to SSRIs.
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00977353
Start Date
April 1 2009
End Date
July 1 2011
Last Update
July 12 2011
Active Locations (1)
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1
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan