Status:
COMPLETED
Functional Magnetic Resonance Imaging (fMRI) Imaging Study in Adolescents With Anorexia Nervosa
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Anorexia Nervosa
Eligibility:
FEMALE
12-18 years
Brief Summary
The purpose of this study is to use fMRI imaging technology to examine areas in the brain related to appetite, reward and cognition in adolescent women with eating disorders as compared to those who h...
Detailed Description
Individuals with anorexia nervosa (AN) have aberrant feeding behavior, disturbances of emotionality and impulse control, and have high rates of relapse after weight restoration (Carter et al., 2004; H...
Eligibility Criteria
Inclusion
- Participants w/ Anorexia Inclusion Criteria
- Female
- Ages 12-18
- Right Handed
- Active AN diagnosis (within last 6 months), excluding amenorrhea criteria
- IBW 70-87% Exclusion Criteria
- Male
- Left Handed
- Does not meet AN criteria within last 6 months
- Alcohol/drug dependence in the 3 months prior to study
- Alcohol/drug use within the 30 days prior to scan. Tox Screen will be administered at GCRC.
- Use of antipsychotic medication in 3 months prior to study (SSRI OK)
- Current diagnosis of severe major effective d/o or anxiety d/o or other psychopathology that might interfere with ability to participate e.g requiring inpatient hospitalization or medication
- Pregnancy or lactation
- Organic brain syndromes, dementia, psychotic disorders or mental retardation
- Neurological or medical disorders such as seizure disorder, renal disease including pyelonephritis and chronic cystitis, impaired renal function including hyponatremia (less than 135meq/l), hypokalemia, raised BUN (more than 15mg/dl), diabetes, thyroid disease (hypo and hyper), EKG indicative of electrolyte imbalance
- Lack of effective birth control during 15 days before the scan. A Urine pregnancy test will be conducted within 24 hours of the scan
- Insufficient English
- Healthy Volunteer Participants Inclusion criteria
- Female
- Ages 12-18
- Right Handed
- IBW between 90% and 120% Exclusion Criteria
- Male
- Left Handed
- Current or past psychiatric (definitive Axis I) disorder
- Alcohol/drug use within the 30 days prior to scan
- Pregnancy or lactation
- Organic brain syndromes, dementia, psychotic disorders or mental retardation
- Neurological or medical illness as indicated by lab tests, medical and psychiatric histories and physical examination
- Any stigmata suggestive of eating disorder
- Any first degree relatives with an Eating Disorder
- Any first degree relative with a current/past major psychiatric disorder (depression and alcoholism taken on a case by case basis and measured by severity)
- Insufficient English
Exclusion
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2019
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT00978666
Start Date
June 1 2009
End Date
November 1 2019
Last Update
November 14 2019
Active Locations (1)
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1
UCSD Eating Disorder Treatment and Research Program
La Jolla, California, United States, 92037