Status:
COMPLETED
GLP-1 - Regulatory Mechanism of Postprandial Glycemia
Lead Sponsor:
Ludwig-Maximilians - University of Munich
Conditions:
Healthy Subjects
Gastric Emptying
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Synthetic GLP-1 lowers postprandial (pp) glycemia by stimulating insulin, inhibiting glucagon, and delaying gastric emptying. However, the effects of the endogenous peptide are largely unknown. Using ...
Detailed Description
Two experiments were performed in random order in 12 healthy subjects. After a 50-min basal period subjects ingested a 412 kcal mixed semisolid meal containing 30g oatmeal, labelled with 99mTc-Sn-coll...
Eligibility Criteria
Inclusion
- Healthy subject
- \>=18 years of age
- No medication
Exclusion
- Acute disease
- Metabolic disease
- On medication
- Pregnancy, breast feeding
- Gastrointestinal surgery
- Dyspeptische Symptome (Völlegefühl, Blähungen, abdominelle Schmerzereignisse, Übelkeit, Erbrechen, Sodbrennen)
- Teilnahme an einer klinischen Studie in den vergangenen 6 Monaten
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00980083
Start Date
October 1 2004
End Date
December 1 2007
Last Update
September 18 2009
Active Locations (1)
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1
Department of Internal Medicine II, University of Munich
Munich, Germany, 81377