Status:
COMPLETED
The Influence of Glutamate on Memory in Humans
Lead Sponsor:
University Hospital, Bonn
Conditions:
Healthy Individuals
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The hippocampus is particularly laden with n-methyl-d-aspartate (NMDA) receptors, and is at the same time one of the most important sites in declarative memory. The rationale of this study is that the...
Eligibility Criteria
Inclusion
- German native language or native language level
- Able to give written informed consent
- right-handed
Exclusion
- inability to give written informed consent, underaged minors, contractually incapable persons, persons in legal custody
- any psychiatric, neurological or internal illness
- hematoporphyria (enzyme sickness)
- intake of medication (except oral contraceptives)
- simultaneous participation in other clinical studies
- hypersensitivity to Memantine or other anti-dementia substances, or to D-Cycloserine
- alcohol abuse
- epilepsy
- depression
- serious anxiety or psychosis
- serious kidney insufficiency
- intake of Ethionamide or Isoniazide
- pregnancy or women who are nursing
- liver or kidney problems
- intake of NMDA-antagonists, such as Amantadine, Ketamine, or Dextromethorphan
- vegetarians
- stomach ulcer, if treated with medication
- renal tubular acidosis
- urinary infections (with proteus bacteria)
- recent heart attack, heart failure, or uncontrolled high blood pressure
- intake of L-Dopa, dopaminergic agonists, and anticholinergics
- intake of barbiturates, spasmolytics, Phenytoin, Amantadine, oral coagulators, warfarin, HCT (Hydrochlorothiazide)
- heart or cranial operations
- pacemaker, medication pump (such as insulin pump), hearing aid, removable prosthodontics
- metal in or on body (such as acupuncture needles, artificial limbs, stents, metal splints, clips, implanted electrodes, tattoos, or piercings)
- claustrophobia
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00980408
Start Date
June 1 2008
End Date
August 1 2011
Last Update
December 3 2014
Active Locations (1)
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1
Forschungszentrum Juelich GmbH
Jülich, North Rhine-Westphalia, Germany, 52428