Status:
COMPLETED
Obesity and Antibiotic Tissue Concentration
Lead Sponsor:
MemorialCare
Collaborating Sponsors:
University of California, Irvine
Conditions:
Obesity
Eligibility:
FEMALE
18+ years
Brief Summary
The purpose of this study is to determine whether the dose of prophylactic antibiotics at the time of cesarean delivery requires adjustment in obese and overweight patients in order to achieve optimal...
Detailed Description
The majority of information regarding pharmacokinetics and pharmacodynamics (the action, properties and elimination of a drug in the body) of antibiotics is based on measurements of the serum and plas...
Eligibility Criteria
Inclusion
- Patients at term (\> 37 weeks) undergoing a cesarean delivery.
Exclusion
- Women younger than 18 years,
- Pre-gestational diabetes,
- Chronic hypertension,
- Collagen vascular disease,
- Multiple gestation,
- Contraindications to cefazolin administration (known anaphylactic reaction to penicillins or known cephalosporin allergy),
- Any exposure to cephalosporins in one week prior to cesarean section, OR
- Need for emergent cesarean delivery or diagnosis of chorioamnionitis.
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT00980486
Start Date
June 1 2009
End Date
June 1 2010
Last Update
October 8 2010
Active Locations (2)
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1
Women's Pavilion at Miller Children's Hospital
Long Beach, California, United States, 90806
2
University of California Irvine Medical Center
Orange, California, United States, 92868