Status:
COMPLETED
Interaction in Chronic Obstructive Pulmonary Disease Experiment
Lead Sponsor:
Radboud University Medical Center
Conditions:
Chronic Obstructive Pulmonary Disease
Cardiovascular Disease
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The final purpose of this study is to determine whether bronchodilation and cigarette smoking in Chronic Obstructive Pulmonary Disease (COPD) patients interact, resulting in an increase of cardiovascu...
Detailed Description
COPD currently is one of the most frequent diseases. In more than 80% of COPD patients, the disease is caused by smoking. About half of the COPD patients are active smokers, although smoking is also t...
Eligibility Criteria
Inclusion
- COPD Gold stage II-III (FEV1/FVC\<0,70 and FEV1 30-80% of predicted value).
- Current cigarette smoking (at the time of performing the study).
- Willing to provide written informed consent.
- Refrain from smoking and bronchodilators \> 8 hours (depends on treatment) before the test.
- Registered in one of the recruitment institutes.
Exclusion
- COPD gold stage I or IV.
- Asthmatic component: History of asthma, present asthma by complaints, eosinophilia or reversibility ≥ 10% of predicted.
- Unable to communicate.
- Physically unable to perform any of the tests.
- Non-COPD respiratory disorders.
- Previous lung-volume reduction surgery and/or lung transplantation.
- Evidence of alcohol, drug or solvent abuse.
- Known α-1 antitrypsin deficiency.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00981851
Start Date
September 1 2009
End Date
May 1 2011
Last Update
July 6 2011
Active Locations (2)
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1
University Center for Chronic Diseases Dekkerswald
Groesbeek, Netherlands
2
Primary care, general practitioners
Nijmegen, Netherlands