Status:
COMPLETED
Determinants of Cognitive Impairment After Acute Coronary Syndrome
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
Université Victor Segalen Bordeaux 2
Conditions:
Coronary Syndrome
Eligibility:
All Genders
35-65 years
Brief Summary
The general purpose of the present pathophysiological study is to investigate the relation between cognitive impairment observed after an acute coronary syndrome and the presence of cerebral anatomo-f...
Detailed Description
Cognitive impairment is observed in more than 30% of the patients from 3 to 6 months after an acute coronary syndrome. Executive functions are mainly impaired. Cognition tends to progressively deterio...
Eligibility Criteria
Inclusion
- Male and female
- Age :30 to 65 years
- First acute coronary syndrome occurred 4 ± 1 months before the inclusion
- Able to understand the use of a pocket computer (palm)
- Able to use a pocket computer (palm)
- Able to give informed consent
- Affiliated to social insurance
Exclusion
- Past medical history of stroke
- Diamox® injection contraindication
- Dementia
- History of major depression
- Aphasia
- Severe visual deficiency
- Contra-indication to brain MRI
- Contra-indication to HMPAO
- Contra-indication to Acetazolamide
- Patient under safeguard of justice
- For women, ineffective contraceptive method
- Breast-feeding or Pregnant women
Key Trial Info
Start Date :
September 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT00982176
Start Date
September 1 2009
End Date
May 1 2013
Last Update
April 2 2014
Active Locations (2)
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1
CHU de Bordeaux
Bordeaux, France, 33076
2
Hôpital Cardiologique du Haut-Lévêque (CEPTA)
Pessac, France, 33604