Status:
COMPLETED
Safety and Immunogenicity Study of Candidate HIV-1 Vaccine Given to Healthy Infants Born to HIV-1/2-uninfected Mothers
Lead Sponsor:
Medical Research Council
Collaborating Sponsors:
European and Developing Countries Clinical Trials Partnership (EDCTP)
Conditions:
HIV-1
HIV Infections
Eligibility:
All Genders
Up to 3 years
Phase:
PHASE1
Brief Summary
Objectives: Safety and immunogenicity of MVA.HIVA vaccine in 20-week-old healthy Gambian infants born to HIV-1/2-uninfected mothers. Gross impact of MVA.HIVA on the immunogenicity of EPI vaccines (D...
Eligibility Criteria
Inclusion
- Healthy infants, 19 weeks of age, with weight for age z-scores within 2 standard deviations of normal.
- Have received all standard EPI immunizations according to national immunization programme.
- Written informed consent by parent.
- Mother HIV-1/2-uninfected.
Exclusion
- Acute disease at the time of vaccination (acute disease is defined as the presence of a moderate or severe illness with or without fever). All vaccines can be administered to persons with a minor illness such as diarrhoea, mild upper respiratory tract infection with or without low-grade febrile illness, i.e. axillary temperature of \<37.5 °C ).
- Axillary temperature of ≥ 37.5 °C at the time of vaccination.
- Any clinically significant abnormal finding on screening from biochemistry or haematology at 19 weeks.
- History of allergic disease or reactions likely to be exacerbated by any component of the vaccine, e.g. egg products.
- Presence of any underlying disease that compromises the diagnosis and evaluation of response to the vaccine.
- Invasive bacterial infections (pneumonia, meningitis).
- Any other on-going chronic illness requiring hospital specialist supervision.
- Administration of immunoglobulins and/or any blood products within one month preceding the planned administration of the vaccine candidate.
- Any history of anaphylaxis in reaction to vaccination.
- Research physician's assessment of lack of willingness by parents to participate and comply with all requirements of the protocol, or identification of any factor felt to significantly increase the infant's risk of suffering an adverse outcome.
- Likelihood of travel away from the study area.
- Untreated malaria infection.
- Any other clinical evidence of infection.
Key Trial Info
Start Date :
November 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00982579
Start Date
November 1 2009
End Date
September 1 2011
Last Update
February 3 2012
Active Locations (1)
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1
Medical Research Council Laboratories, The Gambia
Banjul, Fajara, The Gambia