Status:
TERMINATED
A Trial Of CVX-060, An Anti-Angiogenic COVX-Body, In Combination With Sunitinib In Patients With Advanced Renal Cell Carcinoma
Lead Sponsor:
Pfizer
Conditions:
Solid Tumor
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The safety and tolerability of CVX-060 have been established in the first-in-human clinical trial, CVX-060-101. Thus, this phase Ib/II trial is to assess the safety and pharmacokinetics (PK) profiles ...
Detailed Description
On 23-Nov-2010, B1131001 (CVX-060-102) was closed to enrollment due to emerging clinical data which led to a re-assessment of the strategic goals of the PF-04856884 program. The study enrolled the Pha...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed advanced/metastatic solid tumor
- Having received at least 1 prior systemic therapy for the treatment of advanced/metastatic solid tumors
- Histologically or cytologically confirmed renal cell carcinoma with clear cell histology and evidence of metastasis (No previous systemic therapy for the treatment of metastatic renal cell carcinoma)
- Adequate laboratory tests
- Eastern Cooperative Oncology Group (ECOG) 0-1, Life expectancy \> or = 12 weeks and age \> or = 18 years
Exclusion
- Patients intolerant of prior anti-angiogenic agents
- Recent history of bleeding or bleeding disorders
- History of tumors in the brain
- History of heart problems
- History of severe allergic reaction to antibody therapy
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00982657
Start Date
September 1 2009
End Date
March 1 2014
Last Update
November 20 2015
Active Locations (7)
Enter a location and click search to find clinical trials sorted by distance.
1
Premiere Oncology of Arizona
Scottsdale, Arizona, United States, 85258
2
Premiere Oncology, A Medical Corporation
Santa Monica, California, United States, 90404
3
Boston Baskin Cancer Foundation
Southaven, Mississippi, United States, 38671
4
Providence Portland Medical Center
Portland, Oregon, United States, 97213