Status:
COMPLETED
The Maraviroc Central Nervous System (CNS) Study
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Pfizer
Conditions:
HIV Infections
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to describe the Central Nervous System exposure of maraviroc in HIV-1 infected subjects receiving a stable antiretroviral regimen, including maraviroc, at steady state.
Detailed Description
15 HIV-1 infected subjects currently receiving stable antiretroviral therapy will be recruited. At study entry, within 14 days of screening procedures, subjects will commence maraviroc dosed at 150 mg...
Eligibility Criteria
Inclusion
- HIV-1 infected males or females
- signed informed consent
- plasma HIV RNA \< 50 copies/mL at screening and on at least one other occasion over the last 3 months
- currently receiving a stable antiretroviral regimen comprising of:
- tenofovir 245 mg daily
- emtricitabine 200 mg daily
- a boosted protease inhibitor
- no previous protease inhibitor resistance documented on HIV-1 genotypic resistance testing
- Between 18 to 65 years of age, inclusive
- subjects in good health upon medical history, physical exam, and laboratory testing
- Female subjects who are heterosexually active and of childbearing potential (i.e., not surgically sterile or at least two years post menopausal) must practice contraception as follows from screening through completion of the study including 30 days following last dose of study drug:
- barrier contraceptives (condom, diaphragm with spermicide)
- IUD PLUS a barrier contraceptive
- Female subjects of childbearing potential must have a negative pregnancy test.
- Male subjects who are heterosexually active must use two forms of barrier contraception (e.g., condom with spermicide) during heterosexual intercourse, from screening through completion of the study including 30 days following last dose of study drug.
- Have no serologic evidence of active HBV infection evidenced by negative hepatitis B surface antigen and no serologic evidence of hepatitis C virus infection by a HCV antibody or HCV PCR.
- Have screening laboratory results (haematology, chemistry, and urinalysis) that fall within the normal range of the central laboratory's reference ranges unless the results have been determined by the Investigator to have no clinical significance
Exclusion
- current alcohol abuse or drug dependence
- active opportunistic infection or significant co-morbidities including dementia
- current prohibited concomitant medication (as listed in section 4.1.4)
- Have a body mass index (BMI) \> 32
- Contraindication to lumbar puncture examination. Such as:
- Existing neurological diseases
- Bleeding disorders
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00982878
Start Date
September 1 2009
End Date
February 1 2011
Last Update
November 4 2019
Active Locations (1)
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1
Imperial College Healthcare NHS Trust
London, United Kingdom, W2 1NY