Status:
COMPLETED
MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer
Lead Sponsor:
Abramson Cancer Center at Penn Medicine
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18-120 years
Brief Summary
RATIONALE: Diagnostic procedures, such as specialized types of magnetic resonance imaging (MRI), may help in planning radiation therapy that does less damage to normal tissues. PURPOSE: This phase I ...
Detailed Description
OBJECTIVES: * To determine the feasibility of applying established MRI techniques to map functional anatomic regions at potential risk in irradiated normal brain tissue of patients undergoing radioth...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed head and neck cancer that requires radiotherapy to the base of the skull
- No evidence of metastatic disease
- PATIENT CHARACTERISTICS:
- ECOG performance status 0-1
- Life expectancy ≥ 1 year
- Not pregnant
- Negative pregnancy test
- Able to undergo standard CT simulation and radiotherapy treatment planning and delivery, including the capacity to comply with standard immobilization devices to the head and neck for daily irradiation
- Able to undergo standard MRI and deemed capable of complying with the immobilization needs and tasks required for functional MRIs
- No claustrophobia
- No patients with pacemakers, metal fragments in the eye, or certain metallic implants
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00984074
Start Date
October 1 2008
End Date
December 1 2011
Last Update
April 24 2019
Active Locations (1)
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1
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104-4283