Status:
COMPLETED
Safety and Efficacy Study of Avotermin (Juvista) in Female Subjects
Lead Sponsor:
Renovo
Conditions:
Cicatrix
Wound Healing
Eligibility:
FEMALE
18-45 years
Phase:
PHASE1
PHASE2
Brief Summary
To assess safety and toleration, systemic exposure and anti-scarring potential of intradermal avotermin (Juvista) in young females.
Detailed Description
Subjects were to receive two 1cm incisions on the upper, inner aspect of each arm (four wounds per subject). On Day 0 all subjects received intradermal Juvista at a concentration of 50ng/100ul to one...
Eligibility Criteria
Inclusion
- Clinically healthy, female subjects aged 18-45 years
- Weight between 40-150 kg and a BMI within the permitted range for their height using Quetelet's index (15-35 kg/m(squared)). Weight(kg)/height (squared)(m)
- Subjects who use appropriate non-pharmaceutical methods of contraception or are not likely to become pregnant for the duration of the trial
Exclusion
- Subjects who have history or evidence of hypertrophic or keloid scarring or with tattoos or previous scars in the area to be biopsied
- Subjects with a personal history of a bleeding disorder
- Afro-Caribbean subjects are excluded because of the increased susceptibility to hypertrophic and keloid scarring
- Subjects with a skin disorder that is chronic or currently active and which the investigator considers will adversely affect the healing of acute wounds or will involve the areas to be examined in this trial
- Subjects with any clinically significant medical condition that would impair wound healing including significant rheumatoid arthritis, chronic renal impairment, significant hepatic impairment, inadequately or uncontrolled digestive heart failure, active malignancy, immunosuppressive, radiation or chemotherapy within the last three months, a history of radiotherapy to the arm or diabetes mellitus
- Subjects with a history of clinically significant drug hypersensitivity to lignocaine or allergy to surgical dressings to be used in this trial
- Subjects with any clinically significant abnormality following review of pre-trial laboratory data and physical examination
- Subjects who are taking, or have taken, any investigational drugs, long term oral, topical or inhaled corticosteroid therapy, HRT, oral contraceptive pill, other pharmaceutical methods of contraception or anticoagulant drugs in the thirty days prior to Day 0
- Subjects who have evidence of drug abuse
- Subjects who are known to have or had serum hepatitis or who are carriers of the hepatitis B surface antigen or hepatitis C antibody. Subjects with previous vaccination against hepatitis B are not excluded per se
- Subjects who are carriers of the hepatitis B core antibody and who show less than 10 units per litre of Anti-HBs
- Subjects who have previously had a positive result to the test for HIV antibodies, or who admit to belonging to a high risk group and subjects who at any point have a positive pregnancy test
- Subjects who are pregnant or become pregnant during the trial
- In the opinion of the investigator, a subject who is not likely to complete the trial for what ever reason
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2004
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00984581
Start Date
April 1 2003
End Date
August 1 2004
Last Update
September 25 2009
Active Locations (1)
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1
Renovo
Manchester, United Kingdom, M13 9XX