Status:
UNKNOWN
To Investigate the Influence of Ethnicity in Metabolic Disease in Healthy, Overweight and Obese Subjects
Lead Sponsor:
National University Hospital, Singapore
Collaborating Sponsors:
National Medical Research Council (NMRC), Singapore
Conditions:
Healthy
Overweight
Eligibility:
MALE
21-40 years
Brief Summary
The overall objective of this study is to investigate in depth the nature of metabolic physiology, body composition and epigenetic differences of the different phenotypes of overweight and obese indiv...
Detailed Description
Over the past decade, investigators in Singapore have been actively studying the impact of ethnicity on metabolic traits, particularly those related to insulin resistance (detailed in the preliminary ...
Eligibility Criteria
Inclusion
- Ability to give informed consent
- Chinese, Malay or Indian males (aged 21-40)
- Body mass index between 23-30 kg/m2 for the overweight or obese subjects and between 18.5 to 22.9 kg/m2 for the Chinese control group
- Sedentary adults \< 1 episode of exercise \> =30 min/week
- Birth weight between 3-97% percentiles
- Fasting glucose \< 7 mmol/L
- Normotensive, defined as BP \< 140/90 mmHg and not on any antihypertensive agents
Exclusion
- Recent changes in weight of \> 5% over the past 6 months
- Attempts to lose weight (weight not reaching equilibrium, exercises still changing and not in maintenance phase) over the past 6 months
- Significant changes in diet over the past 6 months
- Any use of weight reducing drugs in the past 6 months
- Previous abdominal surgery (and bariatric surgery)
- Any bleeding disorders which would preclude biopsies
- Any use of investigational drugs in the past 6 months
- Known allergy to insulin or local anesthetics
- Known allergy to milk or milk products (eg. Ensure)
- Any serious illness requiring hospitalization or surgery in the past 6 months
- Treatment with medications for hypertension, diabetes mellitus or dyslipidemia, epilepsy, ischemic heart disease
- On anti-platelet agents, non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulants
- Use of any prescription medication that cannot be safely discontinued within 14 days prior to study entry
- Any use of corticosteroids in the past 6 months
- Any other medications that could alter insulin resistance
- History of surgery with metallic clips, staples or stents
- Presence of cardiac pacemaker or other foreign body in any part of the body
- Mother no longer alive or unable to provide information on birth weight
- Born premature (ie. not full term baby \< 37 weeks of gestation age)
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00988819
Start Date
July 1 2009
Last Update
March 2 2010
Active Locations (1)
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1
National University Hospital
Singapore, Singapore