Status:
COMPLETED
Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Hyperalgesia
Eligibility:
MALE
18-55 years
Phase:
NA
Brief Summary
The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, ...
Detailed Description
This project investigates the phenomenon of opioid-induced hyperalgesia (OIH). Opioid analgesics, in addition to their therapeutic anti-nociceptive effects, under some conditions produce pro-nocicepti...
Eligibility Criteria
Inclusion
- Age 18-55
- No active medical conditions
- BMI between 20-30
- Able and willing to perform/tolerate pain procedures
- Able to communicate in English
Exclusion
- Lifetime substance use disorder, except for alcohol abuse/dependence in remission
- Use of opiates in last 3 months
- Ongoing marijuana use
- Acute or chronic pain
- Neurologic or psychiatric condition known to influence cold pressor testing (peripheral neuropathy, major depression, or schizophrenia)
- Current use of prescribed or over the counter pain medications
- Previous adverse reaction to opiate medications or diphenhydramine
- Use of tobacco or caffeine on study days
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00991809
Start Date
February 1 2009
End Date
May 1 2010
Last Update
October 6 2017
Active Locations (1)
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1
Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States, 21224