Status:
COMPLETED
A Comparison of the Effect of Dorzolamide and Timolol on Optic Disk Blood Flow in Patients With Open Angle Glaucoma
Lead Sponsor:
Medical University of Vienna
Conditions:
Glaucoma, Open-Angle
Eligibility:
All Genders
19+ years
Phase:
PHASE2
PHASE3
Brief Summary
Glaucoma is one of the most common causes of blindness in the industrialized nations. For a long time glaucoma has been defined as a disease in which high intraocular pressure (IOP) leads to irreversi...
Eligibility Criteria
Inclusion
- Men and women older than 19 years
- Primary open angle glaucoma or ocular hypertension with IOP higher than 22 mmHg in at least one eye
- Washout period for previous antiglaucoma treatment: two weeks for adrenergic agonists, one week for parasympathomimetic agents
Exclusion
- Exfoliation glaucoma, pigmentary glaucoma
- History of acute angle closure
- Intraocular surgery or argon laser trabeculoplasty within the last 6 months
- Ocular inflammation or infection within the last 3 months
- Contact lenses
- Patients with bradycardia (heart rate less than 50 beats/min)
- Second or third degree heart block
- Asthma
- COPD
- Congestive Heart Failure
- Severe renal impairment (Creatinine clearance less than 1.8 l/h
- History or hypersensitivity to one of the study drugs or drugs with similar chemical structure
- History of non-IOP responder to beta-blockers or carbonic anhydrase inhibitors
- Pregnancy
Key Trial Info
Start Date :
May 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2003
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT00991822
Start Date
May 1 1999
End Date
December 1 2003
Last Update
October 8 2009
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Vienna, Austria, 1090